Keytruda Now FDA-Approved for Patients with Melanoma

Melanoma

The KEYNOTE-054 Phase 3 clinical trial (NCT02362594) showed that the immune checkpoint inhibitor drug Keytruda decreased the risk of melanoma recurrence or death by 43% in comparison to a placebo drug. The drug has thus been approved by the U.S. Food and Drug Administration (FDA) to treat patients with stage-3 melanoma (cancer has spread to […]

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Research Team Discovers New Immune “Checkpoint” Protein

immunotherapy

A recent report in the journal┬áCell showed that a team led by Vanderbilt researchers has found a new “checkpoint” protein on immune system cells in active, malignant tumors. In mouse models, blocking this protein, along with using other treatments, has been an effective approach to treating cancerous cells. Checkpoint proteins are an important component of […]

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How Charlotte Trainer Beat Stage-4 Cancer at CHIPSA Hospital!

Charlotte Trainer Cancer CHIPSA

How Charlotte Trainer Beat Stage 4 Cancer at CHIPSA Hospital Charlotte Trainer thought she was out of options when she was diagnosed with Stage-4 inoperable Endometrial cancer in November of 2017. After having a full hysterectomy and 25 rounds of radiation, her doctors told her that the cancer had metastasized to her lungs. There was […]

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Study Shows Better Immunotherapy Outcomes in Tumors with More Mutations

Immunotherapy

A recent study published in┬áNature Genetics called “Tumor mutational load predicts survival after immunotherapy across multiple cancer types” revealed that tumors with more mutations had better results with immunotherapy treatment. The study looked at data from 1,662 metastatic cancer patients who received checkpoint inhibitor therapy, and data from over 5,000 patients who were not treated […]

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Researchers Use AI to Improve Immunotherapy Outcomes

immunotherapy

A research team from the University of Maryland is utilizing artificial intelligence (AI) to determine the most effective ways to treat cancer patients with immunotherapy. Immunotherapy takes advantage of the body’s own immune system to fight off cancer, and in the past decade, it has been very successful in treating patients with localized and advanced […]

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Phase 3 Trial Tests Tyvyt as Esophageal Cancer Therapy

esophageal cancer

The ORIENT-15 Phase 3 clinical trial evaluating Tyvyt (sintilimab injection) combined with chemotherapies Taxol (paclitaxel) and Platinol (cisplatin) as treatment for esophageal squamous cell carcinoma is now underway. Tyvyt was developed by Innovent Biologics and Eli Lilly and Company in China as an immune checkpoint inhibitor that will work against PD-1, a protein found on […]

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