Breakthrough HLA mismatched VG-5000 Finally Arrives At CHIPSA Hospital!
– Valentin Ivanovich Govallo, considered by many to be the founder of Immunotherapy in Russia, pioneered placental based therapies that train your immune system to attack and kill cancer. These placentas are full term and usually thrown away after labor.
– In the 1970s, he treated over 35 patients with various solid tumor carcinomas (lung cancer, breast cancer, colorectal, melanoma) and reported a 65% 10 year survival rate. Unfortunately at the time a detailed understanding of how his therapy works had yet to be demonstrated.
– Today, several independent research publications have validated that there are many antigens found in the placenta that are shared with almost all solid tumor carcinomas.
– This therapy is currently exclusively available to patients at the CHIPSA Hospital, and we would like to evaluate whether you are an ideal candidate for therapy.
– Gavallo’s book “The immunology of Pregnancy and Cancer” was written 30 years before science knew what was really happening.
– FDA trials with vaccines using Gavallo’s theory are underway in the US
– A previous version of this vaccine was used at CHIPSA for over 250 patients with verified complete responses in terminal, Stage 4 Cancer patients that were sent home to die.
The potential of utilizing the body’s own natural defenses to seek and kill cancer has fascinated researchers for over one hundred years. Rapid technical innovations in the field of genomics, molecular, and cellular biology are paving the way for a new era of effective immunotherapies for the treatment of cancer.
It has long been understood that certain cancers express a number of identifying molecular features or antigens on their cell surface that can be recognized by the body’s immune cells. The problem is that cancer takes several steps toward evading or escaping detection from the immune system. One of the primary methods that the tumor utilizes to escape destruction from the immune system is by promoting a locally immunosuppressive environment that prevents your body’s immune cells from functioning properly. Essentially, the tumor is able to create a tolerogenic environment that tells your immune system to “leave me alone!”
The concept of using a therapeutic intervention to create or break immunological tolerance in the body has been one of the key pillars of the booming immunotherapy industry. Many researchers have been working to modulate immunological tolerance in the body through novel vaccine therapies, the goal of which is to stimulate an immune response against antigens specific to cancer.
Dr. Valentin Ivanovich Govallo’s Immunotherapeutic Approach to Treating Cancer
In this article we would like to review the work of Dr. Valentin Govallo, a clinical and tumor immunologist from Moscow who is considered by many to be the founder of Immunotherapy in Russia. Dr. Govallo, throughout his lifetime, accumulated over 40 years of experience in clinical immunology, was the author of 294 scientific papers and 19 scientific books. The International Biographical Committee in Cambridge also awarded Govallo with “Man of the Year 2000” he was included with 2000 other outstanding scientists who made an impact during the 20th century. Most recently, in 1993, Govallo published his book “Immunology of Pregnancy and Cancer” with the publishing house Nova Science which documented his most notable scientific discoveries.
Govallo was interested in the development of a novel cellular based cancer immunotherapy he called “immunoplacental therapy (IPT)”, which consisted of chorionic villi extractions from a human placenta following a full term delivery. Govallo was initially obsessed during the 1970s with the remarkable similarities in endocrine profiles between placental and cancer tissue.1 Govallo viewed the placenta as a unique biological phenomenon that can be used to study cancer due to several shared features with established tumors:
- The fetus with foreign paternal antigens behaves similar to a tumor and is not rejected by the mother’s immune system. Tolerance is created to new antigens that the immune system should target and kill.
- The placenta causes immunosuppression locally, supporting this tolerogenic environment.
- There exists in the placenta a hyper-proliferation of blood vessels not normally found in the body except within cancer.
Govallo’s original theory was that placental antigens could be used to stimulate an immune response against the cancer itself. To further pursue his original theory, Govallo conducted two clinical studies in humans to evaluate his immunotherapeutic methods of treating cancer.
His first study was conducted in 1973, where he developed an integrative protocol to treat cancer that consisted of methods of immune stimulation and targeted vaccine therapy. He stimulated the immune system through passive lymphocyte transfer, stimulation, and co-administration of adjuvant BCG to drive an immune response. Govallo, also included in this protocol an autologous tumor cell vaccine and an embryonic cell (non-placental tissue) injection. The study consisted of 66 patients with a range of malignant solid tumor carcinomas. The three, five, and ten year survival rates for this therapy were 12%, 6%, and 2% respectively across all cancer indications.3
Govallo was unimpressed with the results of his original study and conducted a second clinical trial in 1975 with a new approach to stimulating the immune system. In his second study, Govallo took placental extracts from full term deliveries and used them to develop his novel cancer vaccine therapy dubbed the “Immunoplacental Therapy.” This clinical study focused on cancers of the breast (18 patients), lung (7 patients), malignant hemangiopericytoma (10 patients), synovial sarcoma (10 patients), and colorectal cancer (10 patients). The aggregated three, five, and 10 year survival rates for this study were 88%, 77%, and 65% respectively.3 Govallo’s results were fascinating, however he still did not have a defined molecular basis for the vaccines observed effectiveness.
Govallo’s initial research set the stage for many new scientists to further explore the link between pregnancy and cancer with the goal of developing less toxic therapies to replace the conventional medicine approach to treating solid tumors.
Interestingly enough, shortly after Govallo began his clinical studies in Russia, another independent group of scientist in Canada replicated his work in animal models using placental tissue as a vaccine therapy, and they published their work in the British Journal of Cancer in 1978.2 Similarly, this group hypothesized that the vaccine could induce a heightened state of immunity against antigens shared with the placenta and cancer. They identified a subset of antigens that could potentially be shared with the placenta and cancer in their work.
Within the past 10 years, advancements in molecular biology, and genomics have unveiled a plethora of antigens that are shared between the placenta and several histologically distinct tumors. The following table outlines some of the antigens common to both cancer and placental tissue:
|Table 1||Antigens Shared Between Specific Cancers and Placental Tissue|
|Melanoma||Angiogenesis antigens: EGFR30, TEM-131, Endoglin32|
Tumor associated antigens: Cancer testes antigens (MAGE, NY-ESO-1, SSX antigen)4,5, glypican-327, survivin9
|Colon||Angiogenesis antigens: EGFR33 , Endoglin, VEGF34, TEM-134|
Tumor associated antigens: CEA, CSA, SP16, PLAP, HCG, HPL, AFP, FE, TF7, 5T48, survivin9, FasL37
|Ovarian||Angiogenesis antigens: Endoglin36 VEGF-R1, VEGF-R240, TEM-134|
Tumor associated antigens: PLAP, HCG, CEA, AFP, Bjorkland’s antigen10, CTA (SCP-1)11, LK-2612, CA-12513,14, FasL37
|Breast||Angiogenesis antigens: TEM-135, VEGF-R1, VEGF-R2, Endoglin39|
Tumor associated antigens: PLF15, PLAP16, CA-125, CEA14, CD4617, FasL37
|Lung||Angiogenesis antigens: VEGF-R1, VEGF-R242, EGFR, TEM-138, Endoglin42|
Tumor associated antigens: PLAP16, Cancer Testes Antigens (MAGE, SP1)18,19, Ki-1 (CD30) antigen24, CEA, HCG21
|Prostate||Angiogenesis antigens: VEGF, FGF|
Tumor associated antigens: Prostate stem cell antigen (PSCA)20, PSA, HCG21, Cancer Testis Antigen (PAGE)22, FasL37
|Testicular||Angiogenesis antigens:VEGF, EGFR|
Tumor associated antigens: PLAP23 , Ki-1 (CD30) antigen24
Tumor associated antigens: 5T48, PLAP16
|Sarcoma||Tumor associated antigens: Cancer Testis Antigen (XAGE)25, SSX26|
|Lymphoma||Tumor associated antigens: Ki-1 (CD30) antigen24|
|Hepatocellular||Angiogenesis antigens: VEGF-R1, VEGF-R2, EGFR, TEM-138, Endoglin|
Tumor associated antigens: Glypican-327 CTA28
Our Valentin Gavallo 5000, (“VG-5000”), represents the 5th generation of Gavallo’s work.
In the past we have seen the regression of the following cancers using this type of vaccine:
- Stage 4 Prostate Cancer
- Stage 4 Breast Cancer
- Stage 4 Endometrial Cancer
- Stage 4 Lung Cancer
- Stage 4 Leomysarcoma
- Stage 4 Ovarian Cancer
- Stage 4 Melanoma
- Stage 4 Colon Cancer
- Stage 4 Uterine Cancer
- Stage 4 Basal Cell Carcinoma
- Stage 4 Squamous Cell Carcinoma
- Stage 4 Soft-tissue sarcoma
- Stage 4 Osteosarcoma
- Stage 4 Renal Cell Cancer
- Stage 4 Neuroendocrine Cancer
- Stage 4 Mesothelioma
We have seen, first-hand, regression in each of the cancers listed above. Because our genetic makeup varies from person-to-person, results may vary and we cannot guarantee your outcome. However, there is hope, especially for those who have failed conventional standard of care cancer treatment protocols.
During our time using this type of vaccine, we witnessed results that are best described as miraculous. Given the substantial distinctions between cancer types, genetic makeup and pre-treatment history for each of our patients, it makes it difficult for us to publish reproducible data.
Unlike other institutions similar to CHIPSA, we refuse to tarnish the integrity of our doctors and scientists, and we will not diminish the experiences of our past and future patients by publishing fake or misleading statistics. With that focus on integrity and honesty, we can unequivocally state that, at CHIPSA Hospital, we have the most scientifically validated treatments in Mexico, and we are known in respected circles as true innovators in the field of immunotherapy.
We are excited and optimistic to launch our VG-5000 because of the real promise it has for our patients, and because, in our experience, we know it to be very safe and much less caustic than most all other conventional cancer therapies.
- Govallo VI. Immunology of pregnancy and cancer. Nova Science Publishers, Inc.; 1993.
- Vitou CK, Mukherjee BB. A vaccine containing autogenous term placenta and an immunopoteniator to reduce the incidence of autochthonous cancer. Br J Cancer 1978;37: 316–8.
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- Luftl M, Schuler G, Jungbluth AA, et al. Melanoma or not? Cancer testis antigens may help. Br J Dermatol 2004;151: 1213–8.
- Scanlan MJ, Gure AO, Jungbluth AA, et al. Cancer/testis antigens: An expanding family of targets for cancer immunotherapy. Immunol Rev 2002;188:22–32.
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- Skinner JM, Whitehead R. Tumor-associated antigens in polyps and carcinoma of the human large bowel. Cancer 1981;47:1241–5.
- Myers KA, Rahi-Saund V, Davison MD, et al. Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein, An antigen associated with metastasis contains leucine-rich repeats. J Biol Chem 1994;25:9319–24.
- Tsuruma T, Hata F, Torigoe T, et al. Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. J Transl Med 2004;2:19
- Fishman WH, Raam S, Stolbach LL. Markers for ovarian cancer: Regan isoenzyme and other glycoproteins. Semin Oncol 1975;2:211–6.
- Tammela J, Jungbluth AA, Qian F, et al. SCP-1 cancer/ testis antigen is a prognostic indicator and a candidate target for immunotherapy in epithelial ovarian cancer. Cancer Immun 2004;4:10.
- Garin-Chesa P, Campbell I, Saigo PE, et al. Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folatebinding protein. Am J Pathol 1993;142:557–67.
- Fuith, Muller-Holzner E, Marth C, et al. Distribution of CA125 in placental tissues. Int J Biol Markers 1989;4: 78–80.
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- Reinerova M, Veselovska Z, Ausch C, et al. Immunosuppressive activity of lymphocyte mitogenesis by breast cancer-associated p43. Neoplasma 1996;43:363–6.
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- Hofman P, His BL, Manie S, et al. High expression of the antigen recognized by the monoclonal antibody GB24 on human breast carcinomas: A preventive mechanism of malignant tumor cells against complement attack? Breast Cancer Res Treat 1994;32:213–9.
- Eifuku R, Takenoyama M, Yoshino I, et al. Analysis of MAGE-3 derived synthetic peptide as a human lung cancer antigen recognized by cytotoxic T lymphocytes. Int J Clin Oncol 2001;6:34–9.
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- Gu Z, Thomas G, Yamashiro J, et al. Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer. Oncogene 2000;19:1288–96.
- Malatesta M, Mannello F, Luchetti F, et al. Prostatespecific antigen synthesis and secretion by human placenta: A physiological kallikrein source during pregnancy. J Clin Endocrinol Metab 2000;85:317–21.
- Prikler L, Scandella E, Men Y, et al. Adaptive immunotherapy of the advanced prostate cancer – cancer testis antigen (CTA) as possible target antigens. Aktuelle Urol 2004;35:326–30.
- Nouri AM, Torabi-Pour N, Dabare AA. A new highly specific monoclonal antibody against placental alkaline phosphatase: A potential marker for the early detection of testis tumor. BJU Int 2000;86:894–900.
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- Zendman AJ, Van Kraats AA, Den Hollander AI, et al. Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis. Int J Cancer 2002;97:195–204.
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